Fertility(Blessing
of God)
The ability to conceive and bear children |
Infertility(Desire
to be Blessed)
The inability of a couple to achieve pregnancy
after 12 months of unprotected intercourse |
| Chances of normal
conception |
|
Primary
infertility affects |
|
25%
within first month of marriage______
75%
within six months of marriage_______
90%
within one year of marriage
Physiological process of conceiving a child is quite complicated
and depends on the proper function of many factors, including the
following, as listed by THE AMERICAN SOCIETY OF REPRODUCTIVE MEDICINES
(ASRM).
-
Production of healthy sperm by the man
-
Production of healthy ovum by the woman
-
Unblocked fallopian tubes that allows the sperm
to reach the ovum
-
The sperm's ability to fertilize the ovum
-
The ability of fertilized ovum to become implanted
in the uterus
-
Adequate embryo quality
|
15
"25%of couples
In childless couples the
cause can be found
|
| Infertility is a very distressing disorder and is
also very complex to deal with! |
|
| Infertility (Desire
to be Blessed) |
|
| |
|
Male
Factors |
Female
Factors |
| Disturbances of spermatogenesis e.g; |
|
| Oligospermia |
 |
| Teratospermia |
| Aspermia |
| Asthenospermia |
| Azoospermia |
| Hypospermia |
| Hormonal deficiency
Impotence Retrograde ejaculation |
|
| Ovulation dysfunction |
 |
| Hormonal imbalance |
| Endometriosis |
| Pelvic inflammatory diseases |
| Tubal obstruction |
| Cervical incompetence |
| |
|
|
Ovulation dysfunction
is commonly associated with
-
Polycystic ovarian disease
-
Lactation amenorrhea syndrome
-
Psychogenic amenorrhea
-
Certain cases of secondary amenorrhea of undetermined
aetiology
-
Post oral contraceptive pill amenorrhea
|
CLOMID(Clomiphen
Citrate tablets)
The first fertility drug
CLOMID (Clomiphene
Citrate) is the treatment of first choice in the management of infertility
in normally oestrogenized, anovulatory women (WHO GROUPII).
(Human Reproduction Update,vol.3, No.4,PP 359-365, 1997.) |
|
|
| |
90%
Success Rate |
80-90% of women who take CLOMID will
ovulate.The
majority of women with "PURE" anovulatory infertility
respond to treatment with CLOMID.
(E Kousta, DM White and S.Franks) |
|
50%
Pregnancy Rate |
More than 50% of women who ovulate will become pregnant
usually within the first 3 to 6 months. |
|
The effectiveness of CLOM1D'
(Clomiphene Citrate) has been clearly demonstrated in the
treatment of infertility associated with oligo-ovulation. (Hughees,
Collins J, Vandekerckhove) A total of 240 consecutive women visiting
a specialist academic fertility unit with a history of infertility,
oligomenorrhoea or amenorrhoea, and normal FSH and estradiol serum
concentration (WHO GROUP II) was prospectively followed. The women
had not been previously treated with ovulation inducing agents.
All patients commenced with CLOMID (Clomiphene
Citrate). |
|
 |
The rate of pregnancy and miscarriage with CLOMID
are close to those expected in a normal fertile population.
(E Kousta, DM White and S Franks)(Department of Obs and Gyne., Imperial
College School of Medicine at St.Mary's London W2 1PG, UK.)
The
primary causes of male infertility are impaired sperm production,impaired
sperm delivery and testosterone deficiency. CLOMID
(Clomiphene Citrate) is extensively trialed and well documented
with proven efficacy in the treatment of Male-infertility and sub-fertility
as CLOMID ;
-
Improves spermatogenesis
-
Improves sperm count
-
Improves sperm motility
SO,
Improves the chances of pregnancy to the normal
conception rate i.e;90%
DOSAGE
For Females, Usually
1- tablet of CLOMID is to be taken orally, daily
for 5 days starting from the 5th day of the cycle.
|
If ovulation occurs but pregnancy
is not established, the same dose is to be repeated for maximum of
six cycles. As soon as the pregnancy is confirmed CLOMID' should be
discontinued. |
|
If no ovulation occurs, increase
the dose to 2 tablets daily for five days. If ovulation occurs but
pregnancy is not established, the same dose is to be repeated for
maximum of six cycles. As soon as the pregnancy is confirmed CLOMID"
should be discontinued. |
For Male
1- tablet daily for about 90 days with a break
of five days after every 25 days. Prescribing Information
Available on the request: |
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