Negative Symptoms of Schizophrenia
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Dulled Emotions |  |
Social Withdrawal |  |
Loss of interest in life | |||||||
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Apathy or lack |
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Lack of spontaneity and flow of conversation |
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Dopamine hypoactivity leads to negative
symptoms
"Dopamine hyperactivity seems to
lead to the positive symptoms of schizophrenia and dopamine under activity
to negative symptoms, therefore, there seems to be inverse level of cortical-sub-cortical
dopaminergic funtion." (Harrison 1999)
| More Potent than Sulpiride.3 Half daily dose than Sulpiride.3 Fewer Side
effects than sulpiride. 3 A Breakthrough in the Treatment of Schizophrenia with Predominant Negative Symptoms |
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| Mechanisam of Action LEVOPRAID 100 (Levosulpiride) provides good control of the negative symptoms of Schizophrenia through selective action on central dopaminergic hypofuntion. This involves specific inhibitory interaction on presynaptic DA2 autoreceptors, with an increase in dopaminergic activity and consequent clinical and behavioral activation. |
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Better response than depot neuroleptics
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- Exhibits Better Therapeutic Response than Depot Neuroleptics.
- Demonstrates High Efficacy & Safety Profile in Young and Elderly Negative Schizophrenics.
- Extrapyramidal/antimuscarinic effects, Sedatioin & Hypotensioni Appear to be Generally Less Frequent and Mild than with Typical Antipsychotics.1-2
- Good Tolerability is Ensured in Elderly Patients.1
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