Pacific Pharmaceuticals' Levopraid 100mg

A Selective Dopamine DA2 Receptor Antagonist LEVOPRAID 100^® Levosulpiride 100mg Tablets
	In Negative Symptoms of Schizophrenia A Selective Dopamine DA2 Receptor Antagonist LEVOPRAID 100 ^{® Levosulpiride 100mg}

Negative Symptoms of Schizophrenia

Dulled Emotions

Social Withdrawal

Loss of interest in life

Apathy or lack
of motivation

Lack of spontaneity and
flow of conversation

Dopamine hypoactivity leads to negative symptoms
"Dopamine hyperactivity seems to lead to the positive symptoms of schizophrenia and dopamine under activity to negative symptoms, therefore, there seems to be inverse level of cortical-sub-cortical dopaminergic funtion." (Harrison 1999)

More Potent than Sulpiride.³ Half daily dose than Sulpiride.³ Fewer Side effects than sulpiride. ³
A Breakthrough in the Treatment of Schizophrenia with Predominant Negative Symptoms
Mechanisam of Action LEVOPRAID 100 (Levosulpiride) provides good control of the negative symptoms of Schizophrenia through selective action on central dopaminergic hypofuntion. This involves specific inhibitory interaction on presynaptic DA2 autoreceptors, with an increase in dopaminergic activity and consequent clinical and behavioral activation.
Better response than depot neuroleptics

Study Design: Open, comparative. No.of Patients: 144 Duration: Six weeks. Results: Levosulpiride showed a trend to be more effective on depressive symptomatology in comparison to the other neuroleptics.

A Breakthrough in the Treatment of Schizophrenia with Predominant Negative Symptoms
Exhibits Better Therapeutic Response than Depot Neuroleptics. Demonstrates High Efficacy & Safety Profile in Young and Elderly Negative Schizophrenics. Extrapyramidal/antimuscarinic effects, Sedatioin & Hypotensioni Appear to be Generally Less Frequent and Mild than with Typical Antipsychotics.^1-2 Good Tolerability is Ensured in Elderly Patients.¹


DOSAGE: 1 Tablet of LEVOPRAID 100 ^® 2 - 3 times daily


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