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LEVOPRAID® 25 Levosulpiride 25mg |
| GERD Makes Their Life Miserable |
| Due to Poor Lower Esophageal Sphincter Tone |
When the esophageal sphincter is weak, it lacks the
strength necessary to hold back stomach contents. Thus erosive stomach
contents are allowed to backup (or reflux) into the esophagus. |
| Poor Esophageal Clearance |
Normally when an episode of reflux occurs the esophagues
has mechanism that quickly push the refluxed materials back into the stomach.
If these mechanism malfunction the errosive stomach contents may remain
in the esophagus for prolonged periods. This can result in irritation
and even damage to the esophageal lining. |
| Levopraid ® 25 A Selective Dopamine DA2 Receptor Antagonist | |
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| Levopraid 25 is more effective than domperidone and placebo to improve the severity of main reflux symptoms. | |||
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Levosulpiride 25mg tid |
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No. of Patients: 30 duration: 12 weeks |
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| Demonstrate better safety profile | |||
| The incidence of side effects with Levopraid 25 is significantly less than Domperidone and Metoclopramide.2 | |||
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| Levosulpiride 25mg Domperidone 10mg Metoclopramide 10mg |
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| Moreover... | ||
Recent studies showed that Cisapride
but not Levosulpiride has structural properties similar to those of class
III antiarrhythmic drugs, which delays repolarization and prolong QT interval.3 |
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| Hence, Levopraid 25 does not cause cardiac arrhythmias. | ||
| Relieves GERD, Functional dyspepsia & IBS With better safety profile |
| Effectively Relives GERD, Functional Dyspepsia & IBS | Better tolerability than metoclopramide and Domperidone. | Doesnot cause cardiac arrhythmias and diarrhoea. | No extrapyramidal side effects. |
| Indication | Dosage | Duration |
| GERD | 1 Tab. TID |
12 Weeks |
| Functional Dyspepsia | 1 Tab. TID |
4 Weeks |
| IBS | 1 Tab.TID |
4--6 Weeks |
Ref 1: Masci et.al., current Therapeutic Research Vol-53, 1993
Ref 2: Corazza GR,Biagi F, Albano O, et al. Levosulpiride in functional dyspepsia:
a multicentric, double-blind,controlled trial. Ital J. Gastroenterol 1996; 28
317-23
Ref 3: Corazza GR and Tonini M Levosulpiride for Dyspepsia and emesis, Clin
drug invest 2000 Feb.19(2) 151-162
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