Pacific Pharmaceuticals's Napreben

Napreben® HARD ON THE PAIN	Napreben® SOFT ON THE GUT
Provides quick pain relief through rapid absorption.	Betaine & Sodium Partially neutralize the gastric acidity thus reducing harmful effects of anti-inflammatory
Napreben® HARD ON THE PAIN	Napreben® SOFT ON THE GUT
(Naproxen Betaine Sodium) Betaine makes naproxen to be rapidly absorbed thus achieves quick serum concentration & better bioavailability4 so onset of pain relief occurs just in 15 minutes	Carboxylic acid of Naproxen is in the undissociated form in Napreben hence,direct gastrolesive effect is reduced
	owest incidence of side effects makes Napreben® well tolerated.

PEAK SERUM TIME		NSAID'S	SIDE EFFECTS 1,2,3
2-3 HRS.	Diclofenac	Napreben	3.67%
2-4 HRS.	Naproxen	Diclofenac	21-31.2%
1-2 HRS.	Naproxen Na+	Naproxen	25%
1 HRS.	Napreben®	Naproxen Na+	20%
3-5 HRS.	Piroxicam	Piroxicam	11-46%
1-2 HRS.	Flurbiprofen	Flurbiprofen	15%
1-2 HRS.	Ibuprofen	Ibuprofen	15-39%
4-5 HRS.	Oxaprozin	Oxaprozin	13-25%

Achieves peak serum Concentration within 1 hour 1,2,3

The most suitable NSAID for the treatment for Chronic,disabling and life long Rheumatic Disorders due to it's:
Better Efficacy Excellent Tolerability Less Side Effects Convenient dosage
	References: 1. G. Spignoli, A fast acting Naproxen derivative for pain relief. II. Clinical trials. European Bulletin of drug research. Volume 4, No-1. January 1996. 2. The journal of international Medical Research -1988: 16:150-156. 3. American journal of Medicine. Vol.80 (Stippl.4-B) April 28,1986. 4. G. spignoli, A fast acting Naproxen derivative for pain relief 1 chemistry Pharmacology & Toxicology European Bulletin of drug research. Volume 4 No. 1 January 1996.
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